Last update
3/26/2026
Research Authors

Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.2
Supplement Facts
Serving Size: 1 Vegetarian Capsule
Amount Per Serving
%DV
Folate (as L-5-Methyltetrahydrofolate calcium salt)
680 mcg°
170%
Vitamin B12 (as methylcobalamin)
300 mcg
12,500%
📅 Last updated:

Top Medical Research Studies

9
Folic acid reduces CHD risk
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.

Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.

The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.

Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.

Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.

As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More

Most Useful Reviews

7.5
Reduces migraines
2 people found this helpful
This formula benefits my brain, heart, and gut health. After halting its use for a month, my migraines returned—proving its effectiveness. Alongside other supplements, I've noticed improvements in my migraine frequency, mood, and energy levels. The product's packaging is excellent, and the capsules are tasteless.
Read More
9
Promotes blood health
1 people found this helpful
This combination supports heart health by maintaining normal homocysteine levels, promoting nerve cell growth, brain health, cognition, and digestive function. It also enhances immune and nervous system functions while helping maintain normal red blood cell production.
Read More
7.5
Important for women
1 people found this helpful
I find this folate and vitamin B12 complex vital for women's health before menopause and during pregnancy. It also contributes positively to heart health, skin, hair, and the nervous system. With B12, its effects are enhanced.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
  • All Researches
9.5
We explored the effects of folate, a form of vitamin B, on heart problems associated with TANGO2-deficiency disorder (TDD). This genetic condition can lead to dangerous heart rhythms that don’t respond well to standard treatments. To dive deeper into this issue, we established patient-derived heart cells, known as iPSC-CMs, to mimic the heart abnormalities seen in TDD.

In our observations, we found that high doses of folate almost completely eliminated arrhythmias in these heart cells. Interestingly, our clinical observations revealed that TDD patients taking multivitamins, particularly those high in B vitamins, experienced a significant reduction in cardiac crises. This suggests that folate may play a critical role in protecting against these life-threatening heart issues.

Our findings not only highlight the potential of folate as an effective treatment but also emphasize the importance of considering dietary supplements in managing cardiac risks in patients with TDD. Thus, we believe that boosting folate intake could offer a valuable strategy to enhance heart health in those affected by this disorder.
Read More
9
Folic acid reduces CHD risk
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.

Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.

The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.

Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
Read More
We explored how vitamin B12 can act as a safeguard against heart damage caused by ischemia/reperfusion (I/R) injury. In our study, we used a mouse model subjected to I/R injury by occluding the left anterior descending coronary artery, followed by 24 hours of reperfusion.

Our aim was to see if high doses of vitamin B12 could improve heart function and reduce damage. Through various evaluations, including echocardiography and biochemical methods, we revealed that vitamin B12 supplementation does indeed help. It mitigates oxidative stress and lowers levels of harmful reactive oxygen species.

Additionally, we found that B12 supplementation reduced cell apoptosis—essentially cell death—in heart tissues. This response was linked to the action of specific signaling pathways, particularly the SIRT3/AMPK pathway. However, we noted that these protective effects diminished when a SIRT3 inhibitor was introduced, indicating the importance of this pathway.

Moreover, RNA sequencing data showed that vitamin B12 also plays a role in reducing inflammation during I/R injury. Overall, our findings suggest that high doses of vitamin B12 might serve as an effective strategy for treating myocardial damage from I/R events, potentially paving the way for new therapies in heart health.
Read More
8
Folate may reduce heart defect risks
In our exploration of the connection between heart health and maternal nutrition, we focused on the role of folate and multivitamin supplements during pregnancy. We investigated how these supplements might help combat the risks posed by total volatile organic compounds (TVOCs)—harmful indoor air pollutants—on developing babies.

We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.

Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
Read More
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.

Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.

As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
Read More

User Reviews

USERS' SCORE
Good
Based on 7 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Reduces migraines
2 people found this helpful
This formula benefits my brain, heart, and gut health. After halting its use for a month, my migraines returned—proving its effectiveness. Alongside other supplements, I've noticed improvements in my migraine frequency, mood, and energy levels. The product's packaging is excellent, and the capsules are tasteless.
Read More
9
Promotes blood health
1 people found this helpful
This combination supports heart health by maintaining normal homocysteine levels, promoting nerve cell growth, brain health, cognition, and digestive function. It also enhances immune and nervous system functions while helping maintain normal red blood cell production.
Read More
7.5
Important for women
1 people found this helpful
I find this folate and vitamin B12 complex vital for women's health before menopause and during pregnancy. It also contributes positively to heart health, skin, hair, and the nervous system. With B12, its effects are enhanced.
Read More
7.5
Supports recovery
1 people found this helpful
I recommend this for my dad post-stroke. His vessels were in poor condition, and he drinks it to support his heart and vascular health.
Read More
7.5
Boosts energy
1 people found this helpful
This excellent product enhances energy and aids in niacin flow, benefiting the nervous system and heart health. The combination of folic acid and vitamin B12 is plentiful and effective for metabolism. The product is flavourless.
Read More

Frequently Asked Questions

7.5
Improved heart rate
1 people found this helpful
I have been using it for about a month and noticed a decrease in my heart rate. I'm really pleased with it and will definitely order more for my relatives!
7.5
Reduces migraines
2 people found this helpful
This formula benefits my brain, heart, and gut health. After halting its use for a month, my migraines returned—proving its effectiveness. Alongside other supplements, I've noticed improvements in my migraine frequency, mood, and energy levels. The product's packaging is excellent, and the capsules are tasteless.
7.5
Reduces heart risks
1 people found this helpful
Folate works with vitamins B6 and B12 to form a coenzyme that lowers homocysteine, which negatively affects the cardiovascular system and heart disease by preventing cell repair.
9
Folic acid reduces CHD risk
We conducted a case-control study to look into how maternal folic acid supplementation affects the risk of congenital heart disease (CHD) in children and whether genetic factors, specifically MTRR gene polymorphisms, play a role in this relationship.

Our research involved 595 children diagnosed with CHD and 605 healthy children. By using a multivariate logistic regression model, we were able to assess the impact of maternal folate intake and the offspring's genetic profiles on the likelihood of developing CHD and its various subtypes.

The findings were quite striking. We observed that children whose mothers took folic acid during pregnancy showed a significantly reduced risk of CHD. Specifically, this included notable reductions in certain types of heart defects such as atrial septal defect and ventricular septal defect. Interestingly, specific polymorphisms in the MTRR gene were also linked to an increased risk of CHD.

Most importantly, we found that when mothers supplemented with folic acid, it appeared to mitigate some of the risks associated with genetic variants in their children. However, we recognize the need for additional studies with larger populations and different designs to confirm these important findings.
We conducted a case-control study examining how maternal serum folate levels during early to mid-pregnancy might influence the risk of congenital heart disease (CHD) in their children. This research involved participants recruited from one of China's leading cardiac care centers between 2015 and 2018, giving us access to a wealth of valuable data.

Through careful matching of CHD cases and non-CHD controls based on maternal age, we wanted to pinpoint whether variations in folate levels—alongside vitamin B12 and homocysteine levels—had any effect on heart disease in infants. Our findings highlighted a concerning trend: low levels of maternal folate were tied to an increased risk of CHD in offspring. Interestingly, we also discovered that unusually high folate levels were associated with elevated risks.

As we reflected on these results, it's clear that there might be a delicate balance when it comes to folate levels during pregnancy. While ensuring adequate folate is essential, the risk associated with excessive levels prompts further questions. Future studies will be crucial to unpacking these relationships and understanding the mechanisms at play.
8
Folate may reduce heart defect risks
In our exploration of the connection between heart health and maternal nutrition, we focused on the role of folate and multivitamin supplements during pregnancy. We investigated how these supplements might help combat the risks posed by total volatile organic compounds (TVOCs)—harmful indoor air pollutants—on developing babies.

We conducted a case-control study involving pregnant women at different stages of gestation, gathering data on their supplement intake, measuring important nutrients in their blood, and assessing their exposure to indoor air pollutants. Our analysis revealed a concerning link between high indoor TVOC levels and increased rates of congenital heart disease (CHD) in newborns.

Excitingly, we found that regular intake of multivitamins, including folate, could help alleviate these risks. This suggests that ensuring proper nutrient intake could be a simple yet effective strategy for expectant mothers living in environments with high indoor pollution levels. Overall, our findings underline the potential protective benefits of folate and a well-balanced diet in promoting heart health for the next generation.
8
Folate improves heart disease outcomes
We investigated how folate treatment, particularly in the presence of specific genetic variations, impacts patients with heart disease and hypertension. The study included 540 individuals diagnosed with coronary heart disease, categorized into three groups based on their treatment: those receiving folic acid, those without it, and a control group with standard treatment.

We discovered that patients who received folic acid along with enalapril showed a significantly lower recurrence rate of cardiovascular events compared to those who did not receive folic acid. Furthermore, the group treated with folic acid exhibited improved cholesterol levels, indicating better heart health outcomes.

Importantly, we noted that a significant portion of the patients possessed the MTHFR C677T gene mutation, potentially impacting their response to treatment. Overall, our findings suggest that folic acid supplementation plays a crucial role in enhancing the treatment effects for patients with coronary heart disease, particularly for those at higher risk due to their genetic background.

By combining gene screening and folic acid treatment, we can potentially improve clinical outcomes in a population that often struggles with managing heart-related issues effectively.

References

  1. Ruan X, Shang W, Lu J, Li Z, Yang J, et al. Maternal multivitamin supplementation mitigates the risk of fetal congenital heart disease associated with high indoor total volatile organic compounds exposure in east china: a case-control study. Environ Health. 2024;23:110. 10.1186/s12940-024-01150-7
  2. Li L, Ou J, Chen Y, Chen Q, Luo M, et al. Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population. J Health Popul Nutr. 2024;43:220. 10.1186/s41043-024-00699-w
  3. Qu Y, Liu X, Lin S, Bloom MS, Wang X, et al. Maternal Serum Folate During Pregnancy and Congenital Heart Disease in Offspring. JAMA Netw Open. 2024;7:e2438747. 10.1001/jamanetworkopen.2024.38747
  4. Ma L, Zeng L, Wang X. MTHFR C677T gene polymorphism in patients with coronary heart disease and hypertension treated with enalapril and folic acid: implications for prognosis. Cell Mol Biol (Noisy-le-grand). 2024;70:142. 10.14715/cmb/2024.70.9.20
  5. Xu W, Cao Y, Stephens SB, Arredondo MJ, Chen Y, et al. Folate as a potential treatment for lethal ventricular arrhythmias in TANGO2-deficiency disorder. JCI Insight. 2024;9. 10.1172/jci.insight.171005
  6. Hjalmarsson C, Backelin C, Thoren A, Bergh N, Sloan JL, et al. Severe heart failure in a unique case of cobalamin-C-deficiency resolved with LVAD implantation and subsequent heart transplantation. Mol Genet Metab Rep. 2024;39:101089. 10.1016/j.ymgmr.2024.101089
  7. Domínguez-López I, Kovatcheva M, Casas R, Toledo E, Fitó M, et al. Higher circulating vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice. J Sci Food Agric. 2024;104:875. 10.1002/jsfa.12976
  8. Qin Y, Shi Y, Yu Q, Yang S, Wang Y, et al. Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway. Biomed Pharmacother. 2023;163:114761. 10.1016/j.biopha.2023.114761
  9. Mohan A, Kumar R, Kumar V, Yadav M. Homocysteine, Vitamin B12 and Folate Level: Possible Risk Factors in the Progression of Chronic Heart and Kidney Disorders. Curr Cardiol Rev. 2023;19:e090223213539. 10.2174/1573403X19666230209111854
Data last updated:
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